Obestatin signalling counteracts glucocorticoid‐induced skeletal muscle atrophy via NEDD4/KLF15 axis
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FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy
Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function. FHL1 increased the myostatin activity on a SMAD reporter and increased myostatin dependent myotube wasting. In mice, independent expression of...
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ژورنال
عنوان ژورنال: Journal of Cachexia, Sarcopenia and Muscle
سال: 2021
ISSN: 2190-5991,2190-6009
DOI: 10.1002/jcsm.12677